Cosmic Cancer Database Access

关于

This skill integrates the COSMIC (Catalogue of Somatic Mutations in Cancer) database directly into your AI-assisted workflow, enabling researchers and bioinformaticians to programmatically retrieve comprehensive cancer genomics data. It provides streamlined access to millions of somatic mutations, the expert-curated Cancer Gene Census, and mutational signatures across both GRCh37 and GRCh38 assemblies. Whether you are identifying drug resistance markers, analyzing gene fusions, or building bioinformatics pipelines, this skill automates the complex authentication and download processes required to work with high-quality oncology data.

主要功能

• Support for both GRCh37 and GRCh38 human genome assemblies
• Python-based integration for processing data with Pandas and Pysam
• Access to specialized datasets including mutational signatures, gene fusions, and resistance mutations
• Programmatic handling of COSMIC authentication and quarterly release updates
• Automated retrieval of somatic mutation and Cancer Gene Census (CGC) data
• 1 GitHub stars

使用场景

• Identifying oncogenes and tumor suppressors for targeted gene panels
• Extracting mutational signature profiles for tumor etiology analysis
• Filtering variant call files (VCFs) against known cancer driver mutations