Which genome assemblies are supported?

The skill supports both the current standard GRCh38 assembly and the legacy GRCh37 assembly commonly used in older research pipelines.

Does this skill provide real-time API access?

This skill primarily facilitates the programmatic downloading of bulk data files and specific datasets from the COSMIC repository for local processing.

Do I need a COSMIC account to use this skill?

Yes, COSMIC requires authentication for data access. Academic users can register for free at the COSMIC website, while commercial users require a license.

Can I use this for drug resistance research?

Yes, the skill specifically supports downloading the Resistance Mutations dataset which includes clinical annotations for drug-resistant variants.

What data formats are available through this skill?

You can retrieve data in several formats including TSV, CSV, and VCF, typically provided in compressed GZIP format for efficient storage and transfer.

COSMIC Cancer Database Access

Name: COSMIC Cancer Database Access
Author: Activer007

byActiver007

0•

数据科学与机器学习

Accesses and manages the COSMIC somatic mutation database for cancer research and precision oncology workflows.

The COSMIC Database skill provides a programmatic interface for Claude to interact with the Catalogue of Somatic Mutations in Cancer, the world's most comprehensive resource for human cancer mutations. It allows researchers and bioinformaticians to download curated datasets including the Cancer Gene Census, mutational signatures, structural variants, and drug resistance data. By automating the retrieval and initial processing of complex genomic files across different genome assemblies like GRCh37 and GRCh38, this skill streamlines cancer genomics pipelines and facilitates data-driven oncology research directly within the Claude Code environment.

主要功能

01Automated downloading of somatic mutation data and Cancer Gene Census

02Support for both GRCh38 and GRCh37 genome assemblies

03Retrieval of structural variants, gene fusions, and copy number alterations

040 GitHub stars

05Integrated Python helper scripts for handling large compressed genomic files

06Programmatic access to mutational signatures (SBS, DBS, ID)

使用场景

01Analyzing mutational signature profiles for tumor samples and cancer cell lines

02Building bioinformatics pipelines that integrate clinical cancer metadata and drug resistance info

03Filtering variant call format (VCF) files against the expert-curated Cancer Gene Census

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add activer007/ordinary-claude-skills cosmic-database

For use in Claude.ai and ChatGPT

Download Skill