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The ENA Database skill provides a robust interface for Claude to interact with the European Nucleotide Archive, a premier global repository for genomic information. It enables the programmatic retrieval of DNA/RNA sequences, raw sequencing reads (FASTQ), and comprehensive genome assemblies using accession numbers or complex metadata criteria. This skill is essential for bioinformaticians and researchers who need to automate data collection, query taxonomic information, or integrate public genomic datasets directly into analysis pipelines while adhering to ENA's API rate limits and best practices.