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Histolab provides a specialized interface for handling gigapixel whole slide images (WSI) in digital pathology pipelines. It simplifies the complex task of identifying tissue regions, filtering out background artifacts, and extracting informative tiles for deep learning model training. By providing multiple tiling strategies—including random, grid, and score-based—and integrated preprocessing filters, it serves as an essential tool for researchers and pathologists building automated analysis systems and preparing high-quality datasets.