Does this skill require an API key?

No, the Open Targets GraphQL API is publicly accessible and does not require authentication for the queries performed by this skill.

What evidence types are included in the association scores?

Scores include data from GWAS catalog, somatic mutations, known drugs, affected pathways, RNA expression, animal models, and literature text-mining.

What is the Open Targets Platform?

Open Targets is a comprehensive resource for identifying and prioritizing therapeutic targets by integrating genetics, omics, and clinical data.

What types of identifiers are supported?

The skill uses Ensembl gene IDs (targets), EFO IDs (diseases), and ChEMBL IDs (drugs) to ensure precise data retrieval.

Can I use this for drug repurposing research?

Yes, the skill can retrieve known drugs for specific diseases and identify alternative targets and indications based on mechanism of action data.

Open Targets Database Explorer

Name: Open Targets Database Explorer
Author: Yezez9

byYezez9

0•

数据科学与机器学习

Queries the Open Targets Platform to identify and prioritize therapeutic drug targets through systematic data integration.

This skill empowers Claude to interact with the Open Targets Platform, a powerful resource for drug discovery that integrates genetics, omics, literature, and chemical data. It allows researchers and developers to systematically search for target-disease associations, evaluate the druggability (tractability) of genes, assess safety liabilities, and explore the clinical development landscape. By providing programmatic access to the Open Targets GraphQL API, the skill facilitates evidence-based target prioritization, drug repurposing research, and competitive intelligence within a streamlined AI workflow.

主要功能

01Assess target tractability and safety liabilities including toxicity concerns.

02Search for drug information, clinical trial phases, and mechanisms of action.

030 GitHub stars

04Retrieve target-disease association scores derived from genetics, pathways, and literature.

05Identify human genetics evidence such as GWAS and rare variant associations.

06Execute custom GraphQL queries to access the full Open Targets data schema.

使用场景

01Evaluating the safety and druggability of potential gene targets during early discovery.

02Prioritizing therapeutic targets for specific diseases based on genetic and clinical evidence.

03Identifying drug repurposing opportunities by analyzing existing indications and mechanisms.

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add yezez9/research-agent opentargets-database

For use in Claude.ai and ChatGPT

主要功能

01Assess target tractability and safety liabilities including toxicity concerns.

02Search for drug information, clinical trial phases, and mechanisms of action.

030 GitHub stars

04Retrieve target-disease association scores derived from genetics, pathways, and literature.

05Identify human genetics evidence such as GWAS and rare variant associations.

06Execute custom GraphQL queries to access the full Open Targets data schema.

使用场景

01Evaluating the safety and druggability of potential gene targets during early discovery.

02Prioritizing therapeutic targets for specific diseases based on genetic and clinical evidence.

03Identifying drug repurposing opportunities by analyzing existing indications and mechanisms.