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This skill streamlines the creation and maintenance of Indirect Treatment Comparison (ITC) analysis pipelines by applying the 'Tidy Modeling with R' (TMwR) philosophy to health economics and outcomes research. It provides a standardized architecture for data validation, preparation, analysis, and reporting, ensuring that complex ITC methods—such as MAIC, STC, and NMA—are implemented with consistent interfaces and robust reproducibility. By leveraging this workflow, researchers and data scientists can reduce coding errors, enhance pipeline maintainability, and satisfy the rigorous documentation requirements typical of Health Technology Assessment (HTA) submissions.